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Stromal Compartment as a Survival Prognostic Factor in Advanced Ovarian Carcinoma
  1. Alexandre Labiche, PhD*,
  2. Natacha Heutte, PhD*,,
  3. Paulette Herlin, PhD*,
  4. Jacques Chasle, MD,
  5. Pascal Gauduchon, PhD* and
  6. Nicolas Elie, PhD*
  1. *Groupe Régional d'Etudes sur le Cancer (GRECAN), and
  2. IUT deCaen, Département Statistique et Traitement Informatique des données, Université de Caen-Basse Normandie (UCBN); and
  3. Département de pathologie, Centre François Baclesse, Caen, France.
  1. Address correspondence and reprint requests to Alexandre Labiche, PhD, Groupe Régional d'Etudes sur le Cancer (GRECAN), Centre François Baclesse, 3 Ave Général Harris, Cedex 05, 14076 Caen, France. E-mail: a.labiche{at}baclesse.fr.

Abstract

Objective: We investigated the prognostic significance of stromal compartment on the overall survival of patients with advanced epithelial ovarian cancer.

Methods: We evaluated retrospectively the stroma proportion of the tumor surgical specimens of 194 patients with stages III and IV disease, using histochemical staining and fully automatic virtual slide processing. The prognostic significance of stroma proportion and clinical parameters were evaluated using log-rank test and Cox regression.

Results: Stroma proportion was found to be an independent prognostic factor by both univariate (P = 0.016) and multivariate analyses (hazards ratio = 1.45, P = 0.011).

Conclusion: The present data indicate that a high stroma proportion is related to a poor prognosis of stage III and IV ovarian carcinomas.

  • Ovarian carcinoma
  • Prognostic factor
  • Stroma
  • Virtual slide

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Footnotes

  • This study was supported by research grants from Ligue Contre le Cancer, Comité de la Manche, Conseil Régional de Basse-Normandie.

  • Alexandre Labiche received a fellowship from the Ligue Contre le Cancer, Comité de la Manche. Nicolas Elie received a fellowship from the Ministère de l'Enseignement Supérieur et de la Recherche.

  • The authors disclose no potential conflicts of interest.

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