Objectives: The objectives of this study were to assess the maximum standardized uptake value (SUVmax) of 18F-fluorodeoxyglucose (18F-FDG) by a primary tumor of endometrial cancer with the use of positron emission tomography/computed tomography (PET/CT) and to assess its association with the clinical importance of the disease.
Methods: 18F-fluorodeoxyglucose PET/CT scan was performed on 44 participants within 2 weeks before surgery. 18F-fluorodeoxyglucose uptake was quantified by calculating the SUVmax. The distribution of cases that scored positive for each of the biological parameters examined was correlated with the SUVmax of the 18F-FDG PET/CT and the glucose transporter-1 expression status obtained by immunohistochemistry.
Results: The mean SUVmax of the primary endometrial cancer tumors was 17.6 (range, 3.04-34.74). There were significant correlations between the SUVmax of the primary tumor and the International Federation of Gynecology and Obstetrics (FIGO) grade (P < 0.001), maximum tumor size (P < 0.001), and glucose transporter-1 expression (P < 0.001). Furthermore, multivariate analysis showed that the FIGO grade was most significantly identified as a relation factor of SUVmax (≥17.6) for endometrial cancer (P = 0.017). The present findings indicate that a significant relationship was seen between the SUVmax and the FIGO grade in endometrial cancer.
Conclusion: We propose that the primary tumor's SUVmax obtained from 18F-FDG PET/CT may be associated with aggressive biological characteristics in endometrial cancer.
- Endometrial cancer
- 18F-FDG PET
- FIGO grade
- Maximum tumor size
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