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The SUVmax of 18F-FDG PET Correlates With Histological Grade in Endometrial Cancer
  1. Keiichiro Nakamura, MD, PhD*,
  2. Junichi Kodama, MD, PhD*,
  3. Yoshihiro Okumura, MD, PhD,
  4. Atsushi Hongo, MD, PhD*,
  5. Susumu Kanazawa, MD, PhD and
  6. Yuji Hiramatsu, MD, PhD*
  1. *Departments of Obstetrics and Gynecology, and
  2. Departments of Radiology, Okayama University Graduate School of Medical, Dentistry and Pharmaceutical Sciences, Okayama City, Japan.
  1. Address correspondence and reprint requests to Keiichiro Nakamura, MD, PhD, Department of Gynecologic Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. E-mail: k-nakamu{at}


Objectives: The objectives of this study were to assess the maximum standardized uptake value (SUVmax) of 18F-fluorodeoxyglucose (18F-FDG) by a primary tumor of endometrial cancer with the use of positron emission tomography/computed tomography (PET/CT) and to assess its association with the clinical importance of the disease.

Methods: 18F-fluorodeoxyglucose PET/CT scan was performed on 44 participants within 2 weeks before surgery. 18F-fluorodeoxyglucose uptake was quantified by calculating the SUVmax. The distribution of cases that scored positive for each of the biological parameters examined was correlated with the SUVmax of the 18F-FDG PET/CT and the glucose transporter-1 expression status obtained by immunohistochemistry.

Results: The mean SUVmax of the primary endometrial cancer tumors was 17.6 (range, 3.04-34.74). There were significant correlations between the SUVmax of the primary tumor and the International Federation of Gynecology and Obstetrics (FIGO) grade (P < 0.001), maximum tumor size (P < 0.001), and glucose transporter-1 expression (P < 0.001). Furthermore, multivariate analysis showed that the FIGO grade was most significantly identified as a relation factor of SUVmax (≥17.6) for endometrial cancer (P = 0.017). The present findings indicate that a significant relationship was seen between the SUVmax and the FIGO grade in endometrial cancer.

Conclusion: We propose that the primary tumor's SUVmax obtained from 18F-FDG PET/CT may be associated with aggressive biological characteristics in endometrial cancer.

  • Endometrial cancer
  • 18F-FDG PET
  • SUVmax
  • FIGO grade
  • Maximum tumor size
  • GLUT-1

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