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Lactic acidosis and hypoglycemia: a metabolic complication of advanced gynecologic malignancy
  1. H. G. Muntz and
  2. E. Brown
  1. Department of Obstetrics and Gynecology, Brigham & Women's and Beth Israel Hospitals, Harvard Medical School, Boston, Massachusetts, USA
  1. Address for correspondence: Dr Howard G. Muntz, Department of Obstetrics and Gynecology, Beth Israel Hospital, 330 Brookline Avenue, Boston MA 02215, USA.


Refractory lactic acidosis and hypoglycemia characterize a paraneoplastic syndrome observed in advanced gynecologic cancer, as illustrated by a patient with a large malignant mixed Mullerian tumor. Massive infusions of sodium bicarbonate and glucose failed to reverse her metabolic abnormalities, and the patient suffered a rapidly fatal course. The biochemical basis for this metabolic complication is reviewed, including how medical intervention can lead to iatrogenic exacerbation of the metabolic imbalance.

  • hypoglycemia
  • lactic acidosis
  • neoplasms
  • neoplasms (embryonal and mixed)
  • tumor hypoglycemia
  • uterine neoplasms.

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