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Nuclear volume and prognosis in ovarian cancer
  1. O. Mogensen*,†,
  2. F. B. SØRensen†,‡,
  3. P. Bichel‡,§ and
  4. A. Jakobsen
  1. * Danish Cancer Society, Department of Immunoserology, Nørrebrogade 44, DK-8000 Aarhus C;
  2. † Stereological Research Laboratory, University of Aarhus, Bartholin Building, DK-8000 Aarhus C;
  3. ‡ University Institute of Pathology, Aarhus University Hospital, DK-8000 Aarhus C;
  4. § Institute of Pathology, Vejle Hospital, DK-7100 Vejle; and
  5. Department of Oncology, Aarhus University Hospital, DK-8000 Aarhus C, Denmark
  1. Address for correspondence: Ole Mogensen, Danish Cancer Society, Department of Immunoserology, Nørrebrogade 44, DK-8000 Aarhus C, Denmark.

Abstract

The prognostic value of the volume-weighted mean nuclear volume (MNV) was investigated retrospectively in 100 ovarian cancer patients with FIGO-stage IB–II (n = 51) and stage III–IV (n = 49) serous tumors. No association was demonstrated between the MNV and the survival or between the MNV and two of five additional parameters: age and amount of residual tumor. However, both in stage IB–II and stage III–IV carcinomas, the MNV increased significantly with increasing tumor grade and DNA-index. Furthermore, FIGO-stage IB–II patients had significantly smaller nuclei than patients with stage III–IV disease.

  • morphometry
  • ovarian carcinoma
  • prognostic parameter
  • stereology.

https://doi.org/10.1046/j.1525-1438.1992.02030141.x

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