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Regression of peritoneal leiomyomatosis after treatment with gonadotropin releasing hormone analogue
  1. F. F. NOGALES*,
  3. J. LINARES,
  4. A. CONCHA and
  5. P. A. CLAVERO
  1. *Departments of Pathology and Obstetrics and Gynecology, University of Granada Medical School, Spain
  1. Address for correspondence: F. Nogales, Department of Pathology, Universidad de Granada, Facultad de Medicina, 18012 Granada, Spain.


A case of a 42-year-old woman with peritoneal leiomyomatosis (PL) unrelated to pregnancy or any other obvious hormonal source is presented. After treatment with leuprolide acetate for six months, a second-look operation revealed that the majority of the nodules totally regressed. The few remaining ones were substantially reduced in size and exhibited histopathologic evidence of fibrotic change. This response to treatment is documented here for the first time. Since this case was not associated with initial abnormally raised hormonal levels, the regression was caused solely by the treatment and not by the removal of any hormonal stimulus. The usefulness of GnRH analogues in the treatment of PL is proposed.

  • disseminata
  • leiomyomatosis
  • leuprolide acetate
  • peritoneum
  • smooth muscle tumor

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