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French Recommendations on the Management of Invasive Cervical Cancer During Pregnancy
  1. Philippe Morice, MD*,
  2. Febrice Narducci, MD,
  3. Patrice Mathevet, MD,
  4. Henri Marret, MD§,
  5. Emile Darai, MD and
  6. Denis Querleu, MD
  1. * Department of Surgery, Institut Gustave Roussy, Villejuif;
  2. Centre Oscar Lambret, Lille;
  3. Hôpital Edouard Herriot, Lyon;
  4. § Hôpital Bretonneau, Tours;
  5. Hôpital Tenon, Paris; and
  6. Institut Claudius Regaud, Toulouse, France.
  7. Department of Obstetrics and Gynecology,
  8. Department of Pathology, All India Institute of Medical Sciences,
  9. § Department of Biotechnology, Ministry of Science and Technology, New Delhi, India.
  1. Address correspondence and reprint requests to Philippe Morice, MD, Department of Surgery, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France. E-mail: morice{at}igr.fr.

Abstract

Background: Cervical cancer is one of the most frequently diagnosed cancers during pregnancy, but the management of such cases remains unclear. A Working Group was set up in 2007 in France to propose national recommendations for the management of pregnant patients with invasive cervical carcinoma.

Methods: The recommendations are based on this literature review conducted by the members of the Working Group.

Results: Management of cervical cancer during pregnancy depends on 5 factors: stage of the disease (and the tumor size), nodal status, histological subtype of the tumor, term of the pregnancy, and whether the patient wishes to continue her pregnancy. In patients with early-stage disease diagnosed during the first 2 trimesters of pregnancy, there is an increasing tendency to preserve the pregnancy while awaiting fetal maturity in patients with absence of nodal involvement. The delivery (when the fetal maturity is attained) should be then performed using a cesarean section.

Conclusions: This article proposes recommendations for the management of pregnant patients with invasive cervical cancer. These recommendations have been validated by the 3 main scientific societies of gynecologic oncology, pelvic surgery, and obstetrics and gynecology in France.

  • Cervical cancer
  • Chemoradiation
  • Neoadjuvant chemotherapy
  • Pregnancy
  • Preservation
  • Staging procedures

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