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Incidental Endometrial Adenocarcinoma in Early Pregnancy: A Case Report and Review of the Literature
  1. Hannuna Karen Yael, MD*,
  2. Putignani Lorenza, PhD,
  3. Silvestri Evelina, MD,
  4. Pisa Roberto, MD,
  5. Angioli Roberto, MD§ and
  6. Signore Fabrizio, MD*
  1. * Department of Obstetrics and Gynaecology, San Camillo-Forlanini Hospital;
  2. Unit of Microbiology, Bambino Gesù Children's Hospital Healthcare and Research Institute;
  3. Department of Pathology, San Camillo-Forlanini Hospital; and
  4. § Department of Obstetrics and Gynaecology, University of Rome, Campus Bio-Medico, Rome, Italy.
  1. Address correspondence and reprint requests to Signore Fabrizio, MD, Department of Obstetrics and Gynaecology, San Camillo-Forlanini Hospital, Circ. ne Gianicolense 87, Rome 00152, Italy. E-mail: fsignore{at}


Endometrial cancer is the most common neoplasia of the female reproductive system, with the highest incidence among uterine malignancies, and is rarely associated with pregnancy. Thirty-five cases of pregnancy-associated endometrial cancer have been reported in literature, of which ours represents the 20th case diagnosed during the first trimester. A 39-year-old woman, gravida 4, para 2, was diagnosed with a focal, well- to moderately differentiated endometrial adenocarcinoma (International Federation of Gynecology and Obstetrics stage IA and grades G1 and G2) after dilatation and curettage (D&C) for a spontaneous abortion. The patient underwent progestational therapy and follow-up hysteroscopies and D&C to preserve fertility; she is alive and well 18 months after diagnosis. Recurrence of endometrial cancer coexisting with early pregnancy has not been reported in the literature. Conservative therapy for early endometrial cancer, diagnosed at the time of pregnancy, may be an option. Routine histologic examination after D&C performed for spontaneous abortion seems advisable.

  • Endometrial adenocarcinoma
  • Early pregnancy
  • Paradoxical event
  • G1 and G2 tumor grades

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