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Epidemiological Characteristics Related to Treatment Failure of Preinvasive Cervical Intraepithelial Neoplasia Among Brazilian Women
  1. Ilce Ferreira Da Silva, PhD*,
  2. Rosalina Jorge Koifman, PhD and
  3. Inês Echenique Mattos, PhD
  1. *Studies and Research Department/Hospital of Cancer - II/Brazilian Cancer Institute; and
  2. Department of Epidemiology and Quantitative Methods in Health/National School of Public Health/Oswaldo Cruz Foundation, Brazil.
  1. Address correspondence and reprint requests to Ilce Ferreira da Silva, PhD, MPH, Hospital of Cancer - II/Brazilian National Cancer Institute - Rua Equador 831, 7th floor, Santo Cristo, Rio de Janeiro, 20220.410 - RJ/Brazil. E-mail: ilceferreira{at}


Objective: To evaluate cervical intraepithelial neoplasia (CIN) treatment failure among women with an altered Papanicolaou test and treated at a public cervical pathology center in Rio de Janeiro, Brazil.

Methods: An exploratory study was carried out in a cohort of women treated for preinvasive cervical cancer, from 1998 to 2000. Epidemiological, clinical, and sociodemographic data were obtained from medical records. Information related to cytological and histological examinations, classified according to the Bethesda System, were cross-tabulated with reports from the main cervical pathology laboratory at the Brazilian Cancer Institute. Conditional probability for treatment failure (12 and 24 months) and hazard ratios were estimated through Kaplan-Meier (log-rank test, 95%) and Cox regression (entry, ≤0.05; removal, ≥0.10).

Results: Mean (SD) follow-up period was 20.75 (20.53) months, and 449 women were treated for CIN-1 or CIN-2/3. There was an increased probability of treatment failure according to age group (37.19% and 57.44% in 12 and 24 months for women >50 years). Women who smoked for more than 10 years were more likely to present treatment failure compared with those who smoked for up to 10 years (33.56% and 22.01% in 12 months; 53.15% and 42.59% in 24 months, respectively). Women older than 50 years showed an independent risk for treatment failure (adjusted hazard ratio, 1.59; 95% confidence interval, 1.04-2.41) compared with women aged between 10 and 29 years.

Conclusions: Age (>50 years) was statistically associated with treatment failure. Duration of tobacco use (>10 years), CIN-2/3 cytology at treatment, glandular involvement, and having more than 4 sexual partners in a lifetime were also associated with failure, reducing statistical significance after adjustment.

  • Cervical cancer
  • Precancerous lesion
  • CIN treatment failure
  • Epidemiology

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  • The present project was supported by research grants relative to cervical cancer epidemiology from the Brazilian National Research Council-CNPq and the Municipal Health Secretariat of Rio de Janeiro, Brazil.