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Aggressive Small Cell Carcinoma of the Ovary, Hypercalcemic Type With Hypercalcemia in Pregnancy, Treated With Conservative Surgery and Chemotherapy
  1. Timothy Chad Mccormick, DO, MS*,
  2. Tyler Muffly, MD*,
  3. George Lu, MD and
  4. Brenda Shoup, MD
  1. *Department of Obstetrics and Gynecology, and
  2. Division of Maternal Fetal Medicine, University of Missouri-Kansas City; and
  3. Division of Gynecologic Oncology, Saint Luke's Cancer Institute, Kansas City, MO.
  1. Address correspondence and reprint requests to Timothy Chad McCormick, Department of Obstetrics and Gynecology, University of Missouri-Kansas City, 2411 Holmes St, Kansas City, MO 64108. E-mail: txdoc27{at}


Background: Small cell carcinoma of the ovary, hypercalcemic type is a rare and aggressive malignancy found in reproductive-age women.

Case: We report a 22-year-old pregnant woman found to have symptomatic paraneoplastic hypercalcemia associated with small cell carcinoma of the ovary, hypercalcemic type. She was primarily treated with conservative surgery and chemotherapy secondary to desired pregnancy. She died of the disease 10 months from primary diagnosis.

Conclusions: Small cell carcinoma of the ovary, hypercalcemic type is a very aggressive type of ovarian malignancy with a poor prognosis.

  • Small cell carcinoma of the ovary
  • Hypercalcemia
  • Pregnancy

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