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Basic Science
CYP1A1 and CYP2D6 Gene Polymorphisms in Israeli Jewish Women With Cervical Cancer
  1. Guy Gutman, MD*,
  2. Tova Morad, MSc†,
  3. Ben Peleg, BSc*,
  4. Chavah Peretz, PhD†,
  5. Amiram Bar-Am, MD*,
  6. Tamar Safra, MD‡ and
  7. Dan Grisaru, MD, PhD*
  1. *Department of Obstetrics and Gynecology,
  2. †Biochemistry Laboratory, and
  3. ‡Oncology Division, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
  1. Address correspondence and reprint requests to Dan Grisaru MD, PhD, Gynecologic Oncology Service, Tel-Aviv Sourasky Medical Center, 6Weizman St, Tel-Aviv 64239, Israel. E-mail: grisaro{at}post.tau.ac.il.

Abstract

Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.

Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method.

Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003).

Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.

  • Cervical cancer
  • CYP
  • Gene polymorphism

http://dx.doi.org/10.1111/IGC.0b013e3181b9fa5d

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