Article Text

PDF
Serum Prolidase Activity and Oxidative Status in Patients With Stage I Endometrial Cancer
  1. Dagistan Tolga Arioz, MD*,
  2. Hakan Camuzcuoglu, MD,
  3. Harun Toy, MD,
  4. Sefa Kurt, MD,
  5. Hakim Celik, PhD§ and
  6. Nurten Aksoy, MD§
  1. *Department of Obstetrics and Gynecology, Medical School, Afyonkarahisar Kocatepe University, Afyonkarahisar;
  2. Department of Obstetrics and Gynecology, Medical School, Harran University, Sanliurfa;
  3. Izmir Aegean Maternity and Women's Health Hospital, Izmir; and
  4. §Department of Biochemistry, Medical School, Harran University, Sanliurfa, Turkey.
  1. Address correspondence and reprint requests to Dagistan Tolga Arioz, MD, Dumlupinar Mah. Menderes Cad. Ozgurler Apt. No. 8/7, 03200, Afyonkarahisar, Turkey. E-mail: dagistantolgaarioz{at}yahoo.com.

Abstract

Introduction: We aimed to investigate the serum prolidase activity, total oxidant status (TOS), total antioxidant capacity (TAC), and total free sulfhydryl (-SH) groups in patients with stage I endometrial cancer.

Methods: Serum prolidase activity, TOS, TAC, and -SH levels were measured in patients with endometrial cancer (n = 23) and controls (n = 25).

Results: Serum prolidase activity and TOS were significantly higher in patients with endometrial cancer than in controls (P = 0.02 and P = 0.02, respectively), whereas TAC and -SH group levels were significantly lower (P = 0.004 and P = 0.001, respectively). There were no differences between surgical stages IA and IB or between stages IB and IC (P = 0.189 and P = 0.161, respectively) with respect to prolidase levels, whereas there was a significant difference between stages IA and IC (P < 0.001).

Conclusions: Increased serum prolidase activity and oxidative stress may be associated with endometrial cancer, and increased serum prolidase activity may be related to local invasion of endometrial cancer.

  • Endometrial cancer
  • Local invasion
  • Oxidative stress
  • Prolidase activity

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.