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Uterine Cancer
Serum Prolidase Activity and Oxidative Status in Patients With Stage I Endometrial Cancer
  1. Dagistan Tolga Arioz, MD*,
  2. Hakan Camuzcuoglu, MD†,
  3. Harun Toy, MD†,
  4. Sefa Kurt, MD‡,
  5. Hakim Celik, PhD§ and
  6. Nurten Aksoy, MD§
  1. *Department of Obstetrics and Gynecology, Medical School, Afyonkarahisar Kocatepe University, Afyonkarahisar;
  2. †Department of Obstetrics and Gynecology, Medical School, Harran University, Sanliurfa;
  3. ‡Izmir Aegean Maternity and Women's Health Hospital, Izmir; and
  4. §Department of Biochemistry, Medical School, Harran University, Sanliurfa, Turkey.
  1. Address correspondence and reprint requests to Dagistan Tolga Arioz, MD, Dumlupinar Mah. Menderes Cad. Ozgurler Apt. No. 8/7, 03200, Afyonkarahisar, Turkey. E-mail: dagistantolgaarioz{at}yahoo.com.

Abstract

Introduction: We aimed to investigate the serum prolidase activity, total oxidant status (TOS), total antioxidant capacity (TAC), and total free sulfhydryl (-SH) groups in patients with stage I endometrial cancer.

Methods: Serum prolidase activity, TOS, TAC, and -SH levels were measured in patients with endometrial cancer (n = 23) and controls (n = 25).

Results: Serum prolidase activity and TOS were significantly higher in patients with endometrial cancer than in controls (P = 0.02 and P = 0.02, respectively), whereas TAC and -SH group levels were significantly lower (P = 0.004 and P = 0.001, respectively). There were no differences between surgical stages IA and IB or between stages IB and IC (P = 0.189 and P = 0.161, respectively) with respect to prolidase levels, whereas there was a significant difference between stages IA and IC (P < 0.001).

Conclusions: Increased serum prolidase activity and oxidative stress may be associated with endometrial cancer, and increased serum prolidase activity may be related to local invasion of endometrial cancer.

  • Endometrial cancer
  • Local invasion
  • Oxidative stress
  • Prolidase activity

https://doi.org/10.1111/IGC.0b013e3181af711e

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