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Review Articles
The Counseling and Management of Young Healthy BRCA Mutation Carriers
  1. Ram Eitan, MD*,†,
  2. Rachel Michaelson-Cohen, MD‡,
  3. Hanoch Levavi, MD*,† and
  4. Uziel Beller, MD‡
  1. *The Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva;
  2. †Sackler School of Medicine, Tel Aviv University, Tel Aviv; and
  3. ‡Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hadassah Medical School, Hebrew University, Jerusalem, Israel.
  1. Address correspondence and reprint requests to Ram Eitan, MD, The Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. E-mail: eitanr{at}clalit.org.il; eitanram{at}yahoo.com.

Abstract

Abstract Although more than 15 years have elapsed since the discovery of the BRCA1 and BRCA2 genes and the associated increased risk of breast and ovarian cancers in mutation carriers, our understanding of the syndrome is still evolving. With the accumulation of knowledge, more questions arise regarding the proper approach to mutation carriers diagnosed as having cancer. Moreover, the number of questions regarding the recommended management methods for healthy carriers and the potential risk-reducing measures is increasing constantly.

In this review, we discuss these issues and summarize contemporary recommendations.

  • BRCA
  • Healthy mutation carriers
  • Counseling

http://dx.doi.org/10.1111/IGC.0b013e3181b33c4a

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