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Distribution of Human Papillomavirus Genotypes in Archival Cervical Lesions in Eastern Inner Mongolian Autonomous Region, China
  1. En-qi Wu, MS*,,
  2. Xiang-hui Yu, PhD,
  3. Xiao Zha, PhD*,,
  4. Guo-nan Zhang, MB*,
  5. Jin-hua Wang, MM§,
  6. Ying Fan, MB*,
  7. Yuan-yu Tang, MB,
  8. Zhi-xin Zhao, MB,
  9. Yong-ge Wu, PhD and
  10. Wei Kong, PhD
  1. *Department of Gynecol Oncology, Sichuan Tumor Hospital, Chengdu;
  2. College of Life Science, Jilin University, Changchun;
  3. Department of Molecular Pharmacology, Sichuan Tumor Hospital, Chengdu;
  4. §Department of Pathology, Inner Mongolia University for Nationalities Affiliated Hospital;
  5. Department of Pathology, The First People's Hospital of Hkorchin;
  6. Department of Pathology, Tongliao People's Hospital, Tongliao, China.
  1. Address correspondence and reprint requests to Xiao Zha, PhD, Department of Molecular Pharmacology, Sichuan Tumor Hospital, Chengdu, China. E-mail: zha530909{at} and Wei Kong, College of Life Science, Jilin University, Changchun 130012 China. E-mail: weikong{at}


Introduction: Human papillomavirus (HPV) is the main etiologic factor for cervical cancer (CC). To investigate the prevalence of HPV types in archival CC and its precursors collected form Tongliao area, which is located in the east of Inner Mongolian autonomous region, China, and compare the genotype distribution of HPV in cervical lesions between Han Chinese and Mongolian.

Methods: The infections of HPV in a total of 175 cases of formalin-fixed, paraffin-embedded samples, including 71 low-grade squamous intraepithelial lesions (LSIL), 27 high-grade squamous intraepithelial lesions (HSIL), and 77 CC were detected by the combination of consensus primers nested polymerase chain reaction (PCR) and type-specific primers nested PCR.

Results: Overall, HPV prevalence was 93.5% in CC, 92.6% in HSIL, and 63.4% in LSIL. Human papillomavirus 16 was the most predominant HPV type in all cervical lesions, detected in 83.1% of CC, 77.8% of HSIL, and 33.8% of LSIL. Human papillomavirus 45 was the second most predominant HPV type in CC (16.9%) and HSIL (11.1%). Human papillomavirus 33 was the second most predominant HPV type in LSIL (8.5%). Human papillomavirus 18, equal with HPV 45, was the second most common type in Mongolian CC (15.6%), whereas in Han Chinese specimens, no HPV 18 was found.

Conclusions: The prevalence of HPV 45 in CC and HSIL in Tongliao area were relatively higher than other regions of China. Comparing the distribution of HPV types in Han Chinese and Mongolian, the prevalence of HPV 18 in CC from Mongolian was significantly higher than that in Han Chinese.

  • Human papillomavirus
  • Type distribution
  • Cervix

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  • This work was supported in part by grants-in-aid 200504024 from the agency of science and technology of Jilin Province and by grants-in-aid 2006J 13-133 from the agency of science and technology of Sichuan Province, China. The work also was partly supported by project 20674029 of National Natural Science Foundation of China (NSFC).