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Patterns of Failure and Prognostic Factor Analyses in Locally Advanced Cervical Cancer Patients Staged by Positron Emission Tomography and Treated With Curative Intent
  1. Kailash Narayan, MBBS, MD, PhD, FRANZCR*,
  2. Richard J. Fisher, PhD,
  3. David Bernshaw, MBBS, FRANZCR*,
  4. Ramdave Shakher, FRACP and
  5. Rodney J. Hicks, MBBS, FRACP
  1. *Division of Radiation Oncology,
  2. Centre for Biostatistics and Clinical Trials,
  3. Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Australia.
  1. Address correspondence and reprint requests to Kailash Narayan, MBBS, MD, PhD, FRANZCR, Locked Bag 1, A'Beckett St, Victoria 8006, Australia. E-mail: mahaguru{at}


Purpose: The aim of this retrospective analysis was to assess whether parameters derived from magnetic resonance imaging (MRI) and positron emission tomography (PET) provide incremental prognostic value compared with International Federation of Gynecology and Obstetrics (FIGO) stage in cervix cancer patients treated with curative intent using concurrent chemoradiotherapy.

Materials and Methods: This was a retrospective study of patients with locoregionally advanced cervical cancer staged by examination under anesthesia and pretreatment MRI and PET. Potential prognostic factors examined were derived from either clinical evaluation (age, FIGO stage, clinical diameter, histology), MRI (corpus invasion, tumor volume), or PET (lymph node metastasis). Outcome measures examined were overall survival, relapse-free survival, time to failure, local failure, nodal failure, and distant failure.

Results: There were 206 eligible patients. The mean potential follow-up was 4.4 years. At 5 years, for all patients, overall survival rate was 59%. For all outcome measures apart from local failure, for which adenocarcinoma histology was the most powerful adverse prognostic factor (HR, 4.29; P < 0.0001), lymph node status on PET was the dominant unifactor and multifactor prognostic factor. Corpus involvement on MRI was significantly associated with nodal involvement on PET but of MRI-derived parameters only tumor volume has prognostic value, limited to time to failure and nodal failure.

Conclusions: Nodal status on PET was the major predictor of outcome in locally advanced cervix cancer treated with chemoradiation and was superior to FIGO staging. Tumor volume measured from MRI appears to be an important predictor of loco-regional relapse.

  • Cervix
  • PET
  • MRI
  • Staging
  • Imaging

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  • Conflict of Interest Notification: There exists no actual or potential conflict of interest.