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A 14-Year-Old Female Patient With FIGO Stage IB Endometrial Carcinoma: A Case Report
  1. Takashi Mitamura, MD*,
  2. Hidemichi Watari, PhD*,
  3. Yukiharu Todo, PhD*,
  4. Takayuki Koshida, MD and
  5. Noriaki Sakuragi, PhD*
  1. *Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo; and
  2. Yakumo General Hospital, Yakumo, Japan.
  1. Address correspondence and reprint requests to Takashi Mitamura, Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. E-mail: pikarun2620{at}


Introduction: This is the second report on the conservative treatment of endometrial carcinoma in a female patient younger than fifteen years. Case A, a 14-year-old teenager, presented with menorrhagia. An endometrial biopsy revealed grade 2 endometrioid adenocarcinoma. The estrogen receptor and progesterone receptor were strongly positive in 60% and 90% of the tumor, respectively. Although she was administered medroxyprogesterone acetate for a month, it was not effective. She underwent standard surgery including a hysterectomy. She was thereafter free of disease 1 year after surgery. No estrogen receptor staining of the surgical specimen was observed, and 30% of the tumor was strongly positive for progesterone receptor. Direct DNA sequencing of exons 7 and 8 of PTEN and the K-ras codon 12 demonstrated the presence of no mutation. In addition, no dominant-negative p53 mutation was found by a yeast functional assay.

Conclusion: A uterine malignancy should therefore be included in the differential diagnosis in a young female patient complaining of abnormal genital bleeding.

  • Endometrial carcinoma
  • Teenager
  • Conservative treatment
  • Gene mutation

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  • Conflict of interest statement: The authors declare that they have no conflicts of interest.