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Nerve-Sparing Radical Vaginectomy: Two Case Reports and Description of the Surgical Technique
  1. Francesco Raspagliesi, MD*,
  2. Antonino Ditto, MD*,
  3. Fabio Martinelli, MD*,
  4. Francesco Hanozet, MD*,
  5. Eugenio Solima, MD*,
  6. Barbara Grijuela, MD*,
  7. Edward Haeusler, MD and
  8. Rosanna Fontanelli, MD*
  1. *Departments of Gynecologic Oncology and
  2. Departments of Anesthesiology, Istituto Nazionale Tumori, Milan, Italy.
  1. Address correspondence and reprint requests to Antonino Ditto, MD, Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy. E-mail: antonino.ditto{at}


Background: Radical vaginectomy (RV) is related to significant bladder dysfunctions. We describe 2 cases of RV with nerve-sparing technique (NSRV).

Case Reports: A 58-year-old woman with a diagnosis of locally advanced cervical cancer underwent neoadjuvant chemotherapy with local and nodal progression of disease. The patient underwent NS radical hysterectomy plus NSRV, with prompt recovery of bladder function. A 14-year-old adolescent girl with a diagnosis of recurrent embryonal-botryoidal rhabdomyosarcoma was referred to us. She underwent 6 courses of chemotherapy with persistent disease. She then underwent NSRV. Two months after the surgical procedure, she was able to void the bladder.

Conclusions: These are the first 2 cases of NSRV reported in literature. This new surgical technique is feasible, with prompt recovery of bladder function.

  • Radical vaginectomy
  • Autonomic pelvic nerves
  • Nerve-sparing technique
  • Bladder dysfunction

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