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Original Articles: Endometrial Cancer
Clinicopathological Features in Endometrial Carcinoma Associated With Lynch Syndrome in China
  1. Yingmei Wang, PhD*,
  2. Fengxia Xue, MD*,†,
  3. Russell R. Broaddus, MD, PhD‡,
  4. Xia Tao, MD†,§,
  5. Su-su Xie, MD‡ and
  6. Yanbin Zhu, MD*
  1. *Department of Obstetrics and Gynecology, General Hospital of Tianjin Medical University, Tianjin, China; Departments of
  2. †Gynecologic Oncology and
  3. ‡Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX;
  4. §Peking University First Hospital, Department of Obstetrics and Gynecology, Beijing, China.
  1. Address correspondence and reprint requests to Fengxia Xue, MD, Department of Obstetrics and Gynecology, General Hospital of Tianjin Medical University, Tianjin 300052, China. E-mail: fengxiaxue1962{at}163.com.

Abstract

Objective: To study the clinicopathological characteristics of Lynch syndrome-associated endometrial carcinoma in China.

Methods: Twenty-seven patients who fulfilled Amsterdam criteria II were classified as having Lynch syndrome-associated endometrial carcinoma (group A), and 331 patients without a family history of cancer were classified as having sporadic endometrial carcinoma (group B).

Results: There were 81 malignancies in 27 families with Lynch syndrome-associated endometrial carcinoma, including colorectal cancer (24.7%), endometrial carcinoma (21.0%), and liver (12.3%), stomach (9.9%), lung (6.2%), and breast (6.2%) cancers. Mean age at the time of diagnosis was 49.7 years in group A and 56.3 years in group B (P = 0.004). Second primary cancers occurred in 33.3% of patients in group A and 5.1% in group B (P = 0.000). The most common second primary cancers were colorectal cancer (44%) and ovarian cancer (22%). The percentage of obese patients was higher in group A (P= 0.013). There was no difference between the 2 groups in incidence of diabetes mellitus or hypertension or in histological type and International Federation of Gynecology and Obstetrics stage. The 5-year survival rates for groups A and B were 96.2% and 79.6%, respectively. Prognosis for group A was better than for group B (P = 0.045).

Conclusions: Some clinicopathological features of Lynch syndrome-associated endometrial carcinoma, such as early onset and multiple primary carcinomas are similar in the Chinese and American/European populations. However, the Chinese population had a unique family cancer distribution that included lung and breast cancers. Well-differentiated grade and good prognosis imply better biobehavior of Lynch syndrome-associated endometrial carcinoma in the Chinese population.

  • Endometrial carcinoma
  • Lynch syndrome
  • Clinicopathological characteristic

https://doi.org/10.1111/IGC.0b013e3181a12fb9

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    Footnotes

    • Supported by Natural Science Foundation of Tianjin (No. 023610911) and Fund From Ministry of Education of China (No. 02014).