Article Text

Download PDFPDF
Second Primary Gynecologic Cancers After Breast Cancer in Turkish Women
  1. Ibrahim Gulhan, MD*,
  2. Sultan Eser, MD,
  3. Cankut Yakut, MD,
  4. Ozgur Bige, MD,
  5. Enver Ilhan, MD§,
  6. Yusuf Yildirim, MD* and
  7. Ugur Saygili, MD
  1. *Departments of Obstetrics and Gynecology, Izmir Training and Research Hospital,
  2. Izmir Cancer Registry Center, Provincial Health Directorate,
  3. Department of Obstetrics and Gynecology, Dokuz Eylul University,
  4. §Department of General Surgery, Izmir Training and Research Hospital, Izmir, Turkey.
  1. Address correspondence and reprint requests to İbrahim Gülhan, MD, İzmir Eğitim ve Araştırma Hastanesi, Kadın Doğum Kliniği, Bozyaka-İzmir Turkey. E-mail: drigulhan{at}


Objectives: To determine the risk of gynecologic cancers among women with previous breast cancer.

Methods: A population-based longitudinal study was conducted using the Izmir cancer registry center's data on 6356 breast cancer patients diagnosed in the period 1992 to 2006. Standardized incidence ratios (SIR) and absolute excess risks (AER) were calculated.

Results: In total, 88 (1.3%) women developed a second primary cancer (other than second primary breast cancers) versus 49.8 expected (SIR, 1.76; 95% confidence interval [CI], 1.43-2.2; AER, 86.9/100.000 patients/y) and 33 of 88 (37.5%) women developed gynecologic cancer (21 endometrial, 8 ovarian, and 4 cervical) versus 8.8 expected (SIR, 4.03; 95% CI, 2.8-5.7; AER, 48.2/100.000 patients/y). High SIR and AER were observed for uterine (SIR,2.2; 95% CI, 1.5-2.7; AER, 35/100.000 patients/y), ovarian (SIR, 3.63; 95% CI, 1.6-7.2; AER, 12.2/100.000 patients/y), and cervical cancer (SIR, 1.68 95% CI: 0.46-4.3; AER, 2.2/100,000 patients/y).

Conclusions: Our data show that women with previous breast cancer have an elevated risk of developing a second primary gynecologic cancer compared with the general population. These patients should be followed up frequently.

  • Breast cancer
  • Gynecologic cancer

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.