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Association of p73 and MDM2 Polymorphisms With the Risk of Epithelial Ovarian Cancer in Chinese Women
  1. Shan Kang, MD*,
  2. Dong-Jie Wang, MSc*,
  3. Wan-Sheng Li, MD*,
  4. Na Wang, MSc,
  5. Rong-Miao Zhou, MSc,
  6. Dong-Lan Sun, MSc,
  7. Ya-Nan Duan, MSc,
  8. Shi-Zhen Li, MSc*,
  9. Xiao-Fei Li, MSc* and
  10. Yan Li, MD
  1. *Department of Obstetrics and Gynecology, Hebei Medical University, Fourth Hospital,
  2. Department of Molecular Biology, Hebei Cancer Institute, Shijiazhuang, China.
  1. Address correspondence and reprint requests to Li Yan, MD, Department of Molecular Biology, Hebei Cancer Institute, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang 050011, China. E-mail: Lykx1962{at}Yahoo.com.cn.

Abstract

Objective: This study was to investigate the association of p73 G4C14-to-A4T14 and Murine Double Minute2 (MDM2) 309T/G, Del1518+/− single nucleotide polymorphisms with the risk of epithelial ovarian cancer (EOC) in Chinese.

Materials and Methods: This hospital-based case-control study included 257 ovarian cancer patients and 257 healthy women who were matched for age. p73 and MDM2 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism.

Results: There were no significant differences in allele frequencies and genotype distributions of the p73 G4C14-to-A4T14 polymorphism between cases and control women (P = 0.55 and 0.20, respectively). The frequencies of the G allele of the MDM2 309T/G polymorphism were significantly lower in ovarian cancer cases (46.7%) than those in healthy controls (54.7%), there was a statistical difference between the 2 groups (P = 0.01). Compared with the T/T genotype, the G allelotype (T/G+G/G genotype) significantly decreased the risk of developing EOC (odds ratio, 0.65; 95% confidence interval, 0.44-0.97). Although MDM2 Del1518+/− genotypes and allele frequencies did not differ between the case and the control groups (P = 0.68 and P = 0.45), Del1518 +/+ genotype tended to increase the risk of mucinous ovarian cancer or earlier ovarian cancer by stratification analysis according to histological subtypes or clinical stage. Besides, there was a significant interaction between p73 G4C14-to-A4T14 and MDM2 309T/G polymorphisms by the likelihood ratio test (P = 0.03; odds ratio, 0.89; 95% confidence interval, 0.80-0.99).

Conclusion: The MDM2 SNP309G allele significantly decreased the risk of EOC and might be a potentially protective factor for EOC development in Chinese women.

  • p73
  • Murine Double Minute2
  • Single nucleotide polymorphism
  • Epithelial ovarian cancer
  • Risk

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Footnotes

  • The authors declared that they had no competing interests.

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