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Comparison of Laparoscopy and Laparotomy for Management of Endometrial Carcinoma: A Meta-analysis
  1. Woong Ju, MD, PhD*,,
  2. Seung-Kwon Myung, MS, MD,§,
  3. Yeol Kim, MD, MPH,
  4. Hyuck Jae Choi, MD, PhD and
  5. Seung Cheol Kim, MD, PhD*,
  1. * Department of Obstetrics and Gynecology, and
  2. Medical Research Institute, School of Medicine, Ewha Womans University, Seoul;
  3. Center for Cancer Prevention and Detection, and
  4. § Smoking Cessation Clinic, National Cancer Center, Goyang; and
  5. Department of Radiology, Asan Medical Center, University of Ulsan, Seoul, Korea.
  1. Address correspondence and reprint requests to Seung Kwon Myung, MS, MD, Center for Cancer Prevention and Detection, National Cancer Center, 809 Madu 1-dong, Ilsandong-gu, Goyang, Gyeonggi 410-769, Korea. E-mail: msk{at}


Background: This meta-analysis was performed to investigate the outcome of laparoscopic surgery for endometrial carcinoma compared with laparotomy.

Methods: We searched the MEDLINE (PubMed), EMBASE, and Cochrane Review databases in September 2007. Three independent evaluators selected the articles according to predetermined selection criteria.

Results: Thirteen comparative studies (5 prospective and 8 retrospective) that met the selection criteria were included. In a fixed-effects meta-analysis, the overall survival and therecurrence rate showed no significant differences between the laparoscopy and the laparotomy groups, with odds ratios of 0.84 (95% confidence interval, 0.64-1.62) and 0.90 (95% confidence interval, 0.49-1.16), respectively. However, the complication rate was lower in the laparoscopy group than in the laparotomy group with an odds ratio of 0.43 (95% confidence interval, 0.32-0.58).

Conclusions: The survival outcome and recurrence rate after laparoscopic surgery for endometrial carcinoma were similar to those in the laparotomy procedures. However, the complication rate was lower after laparoscopy compared with laparotomy.

  • Meta-analysis
  • Laparoscopy
  • Laparotomy
  • Endometrial cancer

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