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Clinical Outcome of ET-743 (Trabectedin; Yondelis) in High-Grade Uterine Sarcomas: Report on Five Patients and a Review of the Literature
  1. Frédéric Amant, MD, PhD*,
  2. An Coosemans, MD*,
  3. Vincent Renard, MD,
  4. Els Everaert, MD and
  5. Ignace Vergote, MD, PhD*
  1. * Division of Gynecological Oncology, Leuven Cancer Institute (LKI), UZ Gasthuisberg, Katholieke Universiteit Leuven;
  2. Department of Medical Oncology, St-Lucas Ziekenhuis Gent; and
  3. Department of Medical Oncology, AZ Nikolaas-Sint-Niklaas, Belgium.
  1. Address correspondence and reprint requests to Frédéric Amant, Division of Gynecological Oncology, Department of Obstetrics and Gynecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium. E-mail: Frederic.amant{at}uz.kuleuven.ac.be.

Abstract

Abstract The clinical impact of ET-743 (trabectedin; Yondelis) in women with leiomyosarcoma and undifferentiated uterine sarcoma in patients previously treated with chemotherapy is investigated. Current data show a clinical benefit in 2/5 patients, of which 1 had a partial remission during 9 months. Pooling the treatment outcomes with literature data, a response in 5 (38%) of 13 patients and a clinical benefit in 7 (54%) of 13 patients for all high-grade uterine sarcomas is calculated. When only uterine leiomyosarcomas are concerned, response rate is 5 (45%) of 11 patients with a clinical benefit in 7 (64%) of 11 patients. These results on the use of ET-743 in uterine sarcoma patients support the conductance of larger trials.

  • Uterine
  • Leiomyosarcoma
  • Yondelis
  • ET-743
  • Trabectedin
  • Sarcoma

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Footnotes

  • Frédéric Amant is clinical researcher, and An Coosemans is an Aspirant of the Fund for Scientific Research-Flanders (FWO-Vlaanderen).

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