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Clinicopathologic Characteristics of Malignant Germ Cell Tumors in the Ovaries of Korean Women: A Korean Gynecologic Oncology Group Study
  1. Ki Heon Lee, MD*,
  2. In Ho Lee, MD*,
  3. Byoung Gie Kim, MD,
  4. Joo Hyun Nam, MD,
  5. Won Kyu Kim, MD§,
  6. Soon Beom Kang, MD,
  7. Sang Young Ryu, MD,
  8. Chi Heum Cho, MD**,
  9. Ho Sun Choi, MD, and
  10. Kyung Tai Kim, MD,
  1. * Department of Obstetrics and Gynecology, Kwandong University, Cheil General Hospital and Women's Healthcare Center;
  2. Department of Obstetrics and Gynecology, Sungkyunkwan University, Samsung Medical Center;
  3. Department of Obstetrics and Gynecology, Ulsan University, Asan Medical Center;
  4. § Department of Obstetrics and Gynecology, Kosin University, Gospel Hospital;
  5. Department of Obstetrics and Gynecology, Seoul National University Hospital;
  6. Department of Obstetrics and Gynecology, Korea Cancer Center Hospital;
  7. ** Department of Obstetrics and Gynecology, Kyemyong University, Dongsan Medical Center;
  8. †† Department of Obstetrics and Gynecology, Chonnam National University, Hwasun Hospital;
  9. ‡‡ Department of Obstetrics and Gynecology, Hanyang University Hospital, Korea.
  1. Address correspondence and reprint requests to Ki Heon Lee, Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, 1-19 Mukjeong-dong, Jung-gu, Seoul 100-380, Korea. E-mail: 1103khl{at}


From January 1995 to December 2000, medical records of 196 patients were collected from 14 hospitals nationwide and were reviewed retrospectively. We evaluated the clinicopathologic characteristics of malignant germ cell tumors in the ovaries of South Korean women and determined the prognostic factors affecting recurrence. The mean patient age was 23.8 years (range, 4-63 years), and the median follow-up period was 67 months (range, 1-128 months). The distribution of the International Federation of Gynecology and Obstetrics stage was as follows: 128 cases (65.3%) in stage I, 27 cases (13.8%) in stage II, 39 cases (19.9%) in stage III, and 2 cases (1.0%) in stage IV. Histologically, immature teratoma was the most common tumor type (n = 68), followed by dysgerminoma (n = 54), endodermal sinus tumor (n = 38), mixed form (n = 24), and choriocarcinoma (n = 12). A fertility-sparing operation was performed in 134 patients, staging operation in 43 patients, and hysterectomy and bilateral salpingo-oophorectomy in 19 patients. Postoperative chemotherapy was administered in 166 patients, and the most common regimen was bleomycin, etoposide, and cisplatin (n = 120). Recurrence was observed in 13 patients (6.8%) and was influenced by the stage of the tumor and patient age (>40 years). The 5-year survival rate was 96.7%. During the follow-up period, 20 patients had 22 pregnancies that resulted in 17 normal deliveries at term and 5 abortions. The results of this study demonstrate that most malignant germ cell tumors of the ovary in Korean women are detected in the early stage and have excellent survival outcomes with conservative operation and platinum-based chemotherapy.

  • Malignant germ cell tumor
  • Ovary
  • Recurrence
  • South Korea
  • Korean Gynecologic Oncology Group

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  • This work was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea.