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Class II Radical Hysterectomy in Low-Risk IB Squamous Cell Carcinoma of Cervix: A Safe and Effective Option
  1. Hong-Bing Cai, PhD*,
  2. Hui-Zhen Chen, MD*,
  3. Yun-Feng Zhou, PhD,
  4. Dao-Mei Lie* and
  5. Han-Yin Hou*
  1. * Departments of Gynecological Oncology and
  2. Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, PR China.
  1. Address correspondence and reprint requests to Yun-Feng Zhou, Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, 430071, PR China. E-mail: chb2105{at}163.com.

Abstract

Aim: The aim of this study was to determine the outcome of class II radical hysterectomy for the treatment of a subset of patients with early cervical cancer.

Method: From September 1995 to September 2003, a total of 480 patients whose conditions were diagnosed with squamous carcinoma of the cervix with a tumor size of no greater than 2 cm and a pathological grade 1 to 2 was enrolled in a cohort study to compare class II and class III radical hysterectomy, with 240 patients in each group. Disease-free survival, overall survival, pattern of recurrences, and morbidity were the end points of observation for this study.

Results: The class II surgery group had 100.0% overall and 98.33% disease-free actuarial 5-year survival rate, whereas the class III surgery group had 100.0% overall and 97.92% disease-free actuarial 5-year survival rate (P = 0.736). Recurrence rate (2.92% in class II vs 2.50% in class III) was not significantly different in the 2 groups (P = 0.779). The operating time, postoperative length of hospital stay, and estimated blood loss at surgery were significantly lower in the group of patients who underwent class II hysterectomy (P = 0.0001, P = 0.0001, and P = 0.001, respectively). The postoperative complications were also significantly lower in patients who received class II hysterectomy.

Conclusions: In treating a subset of patients with tumor size no greater than 2 cm and grade 1 to 2 squamous cell cancer, class II and class III radical hysterectomy are equally effective, but the former has far less complications than the latter.

  • Cervical carcinoma
  • Radical hysterectomy
  • Surgical radicality

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Footnotes

  • This research was supported by a grant from the Health Department of Hubei Province (JX3A17) and Hubei Provincial Science and Technology Department (2007AB056).

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