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Frequency of Pelvic Lymph Node Metastases and Parametrial Involvement in Stage IA2 Cervical Cancer: A Population-Based Study and Literature Review
  1. Hannah van Meurs, MD*,
  2. Otto Visser, PhD,
  3. Marrije R. Buist, PhD*,
  4. Fibo J.W. ten Kate, PhD and
  5. Jacobus van der Velden, PhD*
  1. * Departments of Gynecologic Oncology and
  2. Pathology, Academic Medical Centre; and
  3. Comprehensive Cancer Centre, Amsterdam, the Netherlands.
  1. Address correspondence and reprint requests to Jacobus van der Velden, Department of Gynaecologic Oncology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Email: j.vandervelden{at}


Background: The frequency of lymph node metastases in stage IA2 cervical cancer is reported to range from 0% to 9.7%. Treatment recommendations vary likewise from a cone biopsy to a Wertheim radical hysterectomy and pelvic lymph node dissection. The objective of this study was to get insight into the true frequency of lymph node metastases and/or parametrial involvement in stage IA2 cervical cancer.

Methods: The hospital records of 48 patients with stage IA2 cervical carcinoma who registered from 1994 to 2006 were reviewed, and a literature search was performed.

Results: Of 48 registered patients, 14 were confirmed to have stage IA2. No lymph node metastases or parametrial invasion and recurrences were found. The collated literature data showed a risk of lymph node metastases of 4.8% (range, 0%-9.7%). The presence of adenocarcinoma and the absence of lymph vascular space invasion resulted in a low risk on lymph node metastases (0.3% and 1.3%, respectively). Parametrial involvement has not been reported.

Conclusions: The risk of the selected patients with stage IA2 cervical cancer on lymph node metastases is low. In patients with stage IA2 squamous cell cancer with lymph vascular space invasion, a standard pelvic lymph node dissection should be recommended. Parametrectomy should be included if the nodes are positive. In the other patients, the treatment can be individualized and does not have to include lymph node dissection or parametrectomy.

  • Microinvasive cervical neoplasm
  • Stage IA2
  • Lymph nodes

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