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What is the optimal approach to the administration of intraperitoneal chemotherapy in ovarian cancer?
  1. M. Markman
  1. The University of Texas MD Anderson Cancer Center, Houston, Texas
  1. Address correspondence and reprint requests to: Maurie Markman, MD, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Email: mmarkman{at}


Three well-designed and conducted randomized phase 3 trials have revealed that the intraperitoneal administration of cisplatin-based chemotherapy as primary treatment of small-volume residual advanced ovarian cancer improves both progression-free and overall survivals compared to an all intravenous cisplatin-based regimen. Based on very reasonable extrapolations from existing evidence-based data, a number of possible “options” can be proposed that use the intraperitoneal route for delivery of chemotherapy in this clinical setting

  • chemotherapy
  • cisplatin
  • intraperitoneal chemotherapy
  • ovarian cancer

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