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Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer
  1. A. Jankowska*,
  2. M. Andrusiewicz*,
  3. J. Grabowski*,
  4. E. Nowak-Markwitz and
  5. J. B. Warchol*
  1. * Department of Cell Biology and
  2. Division of Obstetric & Gynecology, Department of Gynecologic Oncology, University of Medical Sciences, Poznan, Poland
  1. Address correspondence and reprint requests to: Anna Jankowska, PhD, Rokietnicka 5D, 60-806 Poznan, Poland. Email: ajanko{at}


A considerable number of biochemical and physiologic studies evaluate the roles of gonadotropins in carcinogenesis. Latest reports show that human chorionic gonadotropin (hCG), and especially its beta subunit, are secreted by a variety of malignant tumors of different origin. However, the mechanism of hCG action and its role in tumor development is not known yet. This study, with the help of reverse transcription-polymerase chain reaction and immunohistochemistry, is an attempt to document the molecular presence of the hCGβ and luteinizing hormone/hCG receptor (LH/hCGR) in the ovarian, endometrial, and uterine cervix cancer tissues. The LH/hCGR, coexpressed with hCGβ, may act as a potential mediator of hCG action in nontrophoblastic gynecological cancers

  • gynecological cancer
  • human chorionic gonadotropin
  • LH/hCGR
  • mRNA of hCGβ and LH/hCG receptor

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