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Multicenter cohort study on treatment results and risk factors in stage II endometrial carcinoma
  1. J. J. Jobsen*,
  2. M.L.M. Lybeert,
  3. E. M. Van Der Steen-Banasik,
  4. A. Slot§,
  5. J. Van Der Palen,
  6. L. N. Ten Cate,
  7. A. Scholten#,
  8. V. Coen**,
  9. E. M.J. Schutter, and
  10. S. Siesling,
  1. * Department of Radiation Oncology, Medisch Spectrum Twente, Enschede, The Netherlands;
  2. Department of Radiation Oncology, Catharina Hospital, Eindhoven, The Netherlands;
  3. Radiotherapeutic Institute Arnhem, Arnhem, The Netherlands;
  4. § Radiotherapy Institute Friesland, Leeuwarden, The Netherlands;
  5. Department of Epidemiology, Medisch Spectrum Twente, Enschede, The Netherlands;
  6. Laboratorium Pathologie Oost Nederland, Enschede, The Netherlands;
  7. # Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands;
  8. ** Zeeuws Radiotherapy Institute, Vlissingen, The Netherlands;
  9. †† Departments of Obstetrics and Gynaecology, Medisch Spectrum Twente, Enschede, The Netherlands;
  10. ‡‡ Comprehensive Cancer Centre Stedendriehoek Twente, Enschede, The Netherlands
  1. Address correspondence and reprint requests to: Jan J. Jobsen, MD, Department of Radiation Oncology, Medisch Spectrum Twente, Haaksbergerstraat 55, 7513 ER Enschede, The Netherlands. Email: j.jobsen{at}


The aim of this study was to report outcome data and prognostic factors from a large cohort of pathologic stage II endometrioid type endometrial carcinoma. One hundred forty-two stage IIA–B patients were included. A central histopathologic review was performed. Follow-up ranged from 2 to 217 months with a median of 61 months. End points of the study were local and locoregional recurrence rates, distant metastasis–free survival (DMFS), disease-free survival (DFS), and disease-specific survival (DSS). The local failure rate was 5.1% for stage IIA patients and 10.8% for stage IIB patients. Grade was the only significant prognostic factor for local failure. With respect to DMFS, DFS, and DSS, grade 3 showed to be the most prominent prognostic factor in multivariate analyses. Lymphvascular space involvement combined with grades 3 and 2 and myometrial invasion greater than 0.5 also showed to be significant for DMFS and DFS. Our study showed grade 3 to be the most important single independent predictive factor for locoregional and distant recurrences in endometrial carcinoma stage II

  • endometrial carcinoma
  • outcome
  • prognostic factors
  • stage II

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