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Epithelioid trophoblastic tumor of paracervix and parametrium
  1. H. T. Noh,
  2. K. H. Lee,
  3. M. A. Lee,
  4. Y. B. Ko,
  5. S. H. Hwang and
  6. S. K. Son
  1. Department of Obstetrics & Gynecology, College of Medicine, Cancer Research Institute, Chungnam National University, Daejeon, South Korea
  1. Address correspondence and reprint requests to: Sung Kyong Son, MD, Department of Obstetrics & Gynecology, College of Medicine, Chungnam National University, 640 DaeSa Dong, Jung-Gu, Daejon 301–721, South Korea. Email: ssk2887{at}


Epithelioid trophoblastic tumor (ETT) is an unusual variant of gestational trophoblastic tumor that is closely related to choriocarcinoma and placental site trophoblastic tumor but shows different morphologic and immunohistochemical features. We report an ETT discovered in paracervix, parametrium, and periadnexal soft tissue of a 44-year-old woman. She underwent laparoscopic surgery and four courses of chemotherapy with a regimen of etoposide, methotrexate, and dactinomycin. ETT has a distinctive growth pattern and immunohistochemical profile. The difficulties and clues in distinguishing ETT from nontrophoblastic lesions are discussed.

  • epithelioid
  • trophoblastic tumor

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