Article Text

Download PDFPDF
A combination of chemoirradiation and chemotherapy for treatment of advanced clear cell adenocarcinoma of the cervix
  1. K. K.L. CHAN*,
  2. P. IP,
  3. P. KWONG,
  4. K. F. TAM* and
  5. H. Y.S. NGAN*
  1. Departments of *Obstetrics and Gynaecology
  2. Pathology
  3. Clinical Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
  1. Address correspondence and reprint requests to: Karen K.L. Chan, MD, Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, 102, Pokfulam Road, Hong Kong, China. Email: kklchan{at}


Clear cell adenocarcinoma of the cervix (CCAC) is an uncommon tumor. No good treatment option has been reported for advanced disease, and the prognosis is generally poor. We report a case of a 14-year-old girl with stage III CCAC. She was given whole-pelvic external irradiation (40 Gy in 20 daily fractions) and high–dose rate brachytherapy with concurrent weekly cisplatin (40 mg/m2), followed by further external irradiation to the parametria with central shield (14 Gy in seven daily fractions). She then received one cycle of carboplatin (area under the curve [AUC] 6) with paclitaxel (175 mg/m2) and two cycles of carboplatin (AUC 4) with gemcitabine (1000 mg/m2 on days 1 and 8) because she developed anaphylactic shock to paclitaxel. Chemotherapy was stopped after the third cycle due to initial poor general condition. However, she gradually improved while on palliative care. Reassessment 6 months later showed no evidence of residual disease, and she remained disease free during a follow-up of 1 year. The complete response in this case suggests that chemoirradiation followed by combination chemotherapy may be a treatment option for advanced CCAC.

  • cervical cancer
  • chemoirradiation
  • clear cell adenocarcinoma
  • gemcitabine
  • paclitaxel

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.