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Paraneoplastic syndrome in vaginal melanoma: a case report and review of the literature
  1. J. Hauspy*,
  2. A. Nevin*,
  3. I. Harley*,
  4. W. Mason,
  5. I. Quirt,
  6. D. Ghazarian§ and
  7. S. Laframboise*
  1. 1 Departments of
  2. * Gynecologic Oncology,
  3. Medicine/Neurology,
  4. Medical Oncology, and
  5. § Pathology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
  1. Address correspondence and reprint requests to: Stephane Laframboise, MD, FRCSC, Assistant Professor, Department of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9. Email: stephane.laframboise{at}


The authors of this article present a case of a woman diagnosed with a vaginal melanoma who developed paraneoplastic syndrome (PNS) soon after diagnosis. A review of the literature regarding PNSs in gynecological malignancies is also described in this article. To our knowledge, this is the first reported case of paraneoplastic cerebellar degeneration with opsoclonus myoclonus secondary to a vaginal melanoma. In addition, our patient had an unusually acute progression to pancerebellar symptoms over the course of 3 weeks. Her paraneoplastic symptoms improved significantly after partial resection of the melanoma.

  • melanoma
  • paraneoplastic syndrome
  • vagina

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