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Ototoxicity after intraperitoneal chemotherapy: a case report
  1. L. Nieves*,
  2. J. Currie,
  3. J. Hoffman and
  4. J. I. Sorosky,
  1. * Department of Obstetrics and Gynecology, Brody School of Medicine of East Carolina University, Greenville, North Carolina;
  2. Department of Obstetrics and Gynecology, Hartford Hospital, Hartford, Connecticut; and
  3. Department of Obstetrics and Gynecology, New Britain General Hospital, New Britain, Connecticut
  1. Address correspondence and reprint requests to: Lucybeth Nieves, MD, Department of Obstetrics and Gynecology, Gynecology Oncology Division, The Brody School of Medicine, 2s-12 Brody Medical Sciences Building, Greenville, NC 27834, USA. Email: lucybethnieves{at}


Recently, the National Cancer Institute endorsed intraperitoneal (IP) therapy as the treatment of choice for optimally debulked epithelial ovarian cancer. However, there are no drug regimens that are clearly indicated, and the exact method of administration has not been established. Furthermore and most importantly, physicians are unaware of what toxicities should be expected with their use of IP therapy. We report a recent unanticipated toxicity from IP cisplatin therapy and review the literature. A 63-year-old female with optimally debulked stage IIIC papillary serous carcinoma of ovary was admitted on postoperative day 14 for her first cycle of IP cisplatin. She received a cisplatin infusion of 100 mg/m2. Four days after the cycle, she suffered acute onset of bilateral tinnitus and hearing loss (ototoxicity grade 3). Thus, we conclude that high-frequency hearing loss remains a potentially serious and permanent adverse effect of cisplatin.

  • cisplatin toxicity
  • intraperitoneal chemotherapy
  • ototoxicity
  • ovarian cancer

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