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Placental site trophoblastic tumor with an ovarian metastasis
  1. D. Milingos*,
  2. D. Doumplis*,
  3. P. Savage,
  4. M. Seckl,
  5. I. Lindsay and
  6. J. R. Smith*
  1. *West London Cancer Centre, Hammersmith Hospitals NHS Trust, London, United Kingdom; and Departments of
  2. Medical Oncology and
  3. Histopathology, Charing Cross Hospital, London, United Kingdom
  1. Address correspondence and reprint requests to: J.R. Smith, MB, ChB, MD, FRCOG, Hammersmith Hospitals NHS Trust, Du Cane Road, London W12 0HS, UK. Email: jrsmithgynaecology{at}


Placental site trophoblastic tumors (PSTT) are the rarest form of gestational trophoblastic disease (GTD). The clinical management of PSTT differs from the other forms of GTD as surgery plays a more important role. The most common metastatic sites are the lung, liver, and vagina while spread to the adnexa is relatively unusual. We describe a case of a 35-year-old woman presenting with PSTT and ovarian metastasis who was successfully treated with radical hysterectomy, bilateral oophorectomy, pelvic lymph node dissection, and postoperative chemotherapy. The case highlights the possibility of ovarian metastases despite normal preoperative imaging and confirms the value of multidisciplinary management of this rare illness

  • gestational trophoblastic disease
  • ovarian metastasis
  • PSTT

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