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The significance of C3435T point mutation of the MDR1 gene in endometrial cancer
  1. P. M. Mrozikiewicz*,
  2. A. Seremak-Mrozikiewicz,
  3. A. Semczuk,
  4. O. Landt§,
  5. G. H. Breborowicz and
  6. K. Drews
  1. *Department of Pharmacology and Biotechnology, Research Institute of Medicinal Plants, Poznan, Poland
  2. Department of Perinatology and Gynecology, University of Medical Sciences, Poznan, Poland
  3. Department of Gynecological Surgery, Lublin Medical School, Lublin, Poland
  4. §TIB Molbiol, Syntheselabor, Berlin, Germany
  1. Address correspondence and reprint requests to: Przemyslaw M. Mrozikiewicz, MD, Research Institute of Medicinal Plants, Libelta 27, 61-707 Poznan, Poland. Email: pmm{at}post.pl

Abstract

The P-glycoprotein (P-gp) plays an important role in carcinogen distribution and is connected with cell differentiation and apoptotic processes leading to carcinogenesis. Interindividual differences in P-gp activity could modulate susceptibility to cancer development. The MDR1 gene, coding for P-gp, is highly polymorphic and some mutations modulate P-gp activity. Recently, association between the MDR1 C3435T polymorphism and the cancer susceptibility was shown. We have hypothesized that MDR1 polymorphism could influence endometrial cancer susceptibility. We have matched 198 women with endometrial cancer and 198 controls. An additional group of 488 healthy volunteers was investigated. The MDR1 C3435T polymorphism was tested by LightCycler assay. The distribution of MDR1 3435 genotypes was significantly different between cases and controls (P= 0.006). Genotypes containing at least one 3435T allele were statistically significant more frequent in the endometrial cancer group (86.8% vs 75.2%, OR 2.18, P = 0.004). Our observation suggests that MDR1 C3435T polymorphism is correlated with endometrial cancer susceptibility.

  • cancer susceptibility
  • endometrial cancer
  • epidemiology
  • MDR1 polymorphism
  • P-glycoprotein

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