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Non-Hodgkin's lymphoma mimicking gynecological malignancies of the vagina and cervix: a report of four cases
  1. D. E. Cohn*,
  2. K. E. Resnick*,
  3. L. A. Eaton*,
  4. J. Dehart and
  5. V. Zanagnolo*
  1. * Departments of Obstetrics and Gynecology, Division of Gynecologic Oncology, Columbus, Ohio
  2. Pathology, The Ohio State University College of Medicine, Columbus, Ohio
  1. Address correspondence and reprint requests to: David E. Cohn, MD, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 320 West 10th Avenue, M-210 Starling Loving Hall, Columbus, OH 43210, USA. Email: david.cohn{at}


Although in the past two decades there has been a sharp rise in the incidence of extranodal primary lymphomas in the United States, non-Hodgkin's lymphoma (NHL) of the female genital tract is still rare. We present four cases of extranodal NHL presenting with signs and symptoms consistent with cancer of the vagina or cervix and lacking the “B” symptoms often associated with systemic lymphoma such as fever, weight loss, night sweat, and fatigue. It is important for gynecologists to be aware of this neoplastic disease and to include cervical or vaginal lymphoma in the differential diagnosis of patients presenting with examinations suggestive of cervical or vaginal cancer. A correct diagnosis leads to the appropriate therapy, and radical gynecological surgery can be avoided for primary cervical and vaginal lymphoma

  • cervical and vaginal cancer
  • crush artifact
  • non-Hodgkin's lymphoma

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