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A comparative profile of the prevalence and age distribution of human papillomavirus type 16/18 infections among three states of India with focus on northeast India
  1. P. Laikangbam*,
  2. S. Sengupta*,
  3. P. Bhattacharya*,
  4. C. Duttagupta,
  5. Th. Dhabali Singh,
  6. Y. Verma§,
  7. S. Roy,
  8. R. Das and
  9. S. Mukhopadhyay#
  1. * Human Genetics Unit, Indian Statistical Institute, Kolkata, India
  2. Institute of Technology and Marine Engineering, Amira, West Bengal, India
  3. Babina Diagnostics Centre, Manipur, India
  4. § Department of Pathology, Sir Thutob Namgyal Memorial Hospital, Sikkim, India
  5. Quadra Diagnostic Centre, Kolkata, India
  6. Child in Need Institute, Daulatpur, West Bengal, India
  7. # Biological Anthropology Unit, Indian Statistical Institute, Kolkata, India
  1. Address correspondence and reprint requests to: Sharmila Sengupta, PhD, Human Genetics Unit, Indian Statistical Institute, 203, B.T. Road, Kolkata 700 108, India. Email: sharmila{at}isical.ac.in; sharmilasg2003{at}yahoo.com

Abstract

Human papillomavirus (HPV) DNA in cervical scrape samples of married women from Manipur (n= 692) and Sikkim (n= 415) in northeast India was determined and compared with that of women from West Bengal (n= 1112) in eastern India by polymerase chain reaction. HPV prevalence was lower in Manipur (7.4%) than in Sikkim (12.5%), which was closely followed by West Bengal (12.9%). HPV18 was predominant in Manipur (2.03%) and strikingly lower (0.2%) in Sikkim and West Bengal (0.9%), while the reverse was true for HPV16. The proportion of HPV16/18 infections in Manipur (3.3%, 22/672) and Sikkim (3.89%, 14/359) were comparable and significantly lower compared to that in West Bengal (7.8%, 79/1007) among women having normal cervical cytology. Such prevalence was similar among all age groups in Manipur: increased with age for women in Sikkim and dropped with age for those in West Bengal similar to that reported previously. At age ≤30 years, HPV16/18 prevalence in Manipur (3.3%) and Sikkim (2.5%) was comparable but was significantly lower (P < 0.05) in contrast to that in West Bengal (8.8%). Among abnormal cytologic lesions, HPV16/18 infections were significantly higher than in normals (P= 0.000) both in Sikkim (14.3%) and West Bengal (20.9%) and absent in Manipur. Such prevalence was noted among women in Sikkim aged >30 years and equally among those in West Bengal aged ≤30 or >30 years. Thus, women from northeast India, particularly from Manipur, appear less susceptible to HPV16/18 infection and related cervical lesions compared to those from West Bengal, where such proneness was prominently evident at age ≤30 years.

  • age-related prevalence
  • general populations
  • HPV infection
  • northeast India

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