Article Text

Download PDFPDF
CYP17 genetic polymorphism in patients with endometrial hyperplasia and cancer
  1. M. Aban*,
  2. M. Arslan*,
  3. E. Tok*,
  4. S. Tekes,
  5. T. Budak and
  6. A. Altintas
  1. * Department of Obstetrics and Gynecology, Mersin University, School of Medicine, Mersin, Turkey
  2. Department of Medical Biology and Genetics, Dicle University, School of Medicine, Diyarbakir, Turkey
  3. Department of Obstetrics and Gynecology, Cukurova University, School of Medicine, Adana, Turkey
  1. Address correspondence and reprint requests to: Murat Arslan, MD, Mersin Universitesi Hastanesi, 33070, Mersin, Turkey. Email: muratarslan{at}


We investigated the association of CYP17 gene polymorphism with the risk of having endometrial cancer and a well-known precursor of it, endometrial hyperplasia. Group A (control group) consisted of 35 patients who had histologically proven normal endometrium. Group B and C consisted of 18 and 30 patients who had endometrial hyperplasia with and without atypia, respectively. Group D consisted of 57 patients who had endometrial cancer. Venous blood samples were collected from patients in groups, and polymerase chain reaction was performed to determine the CYP17 gene polymorphism. Significant increase of A1/A1 and a decrease of A1/A2 genotype frequencies have been determined in patients with endometrial cancer and with atypical endometrial hyperplasia. No significant differences were found between groups in the frequency of A2/A2 genotype. There was no significant difference between the groups in the meaning of allele distributions. CYP17 polymorphism had correlation with endometrial atypia and cancer. Related effects of different types of CYP17 gene variants on the progression of hyperplastic endometrial cells into carcinoma should be evaluated in further studies. Progress in this area would help us modulate preventive treatments used in those actual high–risk group patients.

  • cancer
  • CYP17
  • endometrium
  • gene
  • hyperplasia
  • polymorphism

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.