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Devastating effects of chemotherapy: deafness and acute renal failure in a patient with epithelial ovarian cancer
  1. M. Ozguroglu,
  2. O. Sari and
  3. H. Turna
  1. Section of Medical Oncology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
  1. Address correspondence and reprint requests to: Mustafa Ozguroglu, MD, Çiçekçi Bostan Sok., Mesa Koru Evleri C1/1, Altunizade 81200, İstanbul, Turkey. Email: ozguroglu{at}


Paclitaxel and platinum combination is the standard chemotherapy regimen for patients with advanced epithelial ovarian cancer. The dose-limiting toxicity effects of this combination are myelosuppression and neuropathy. Herein, we report a case of a 71-year-old female with advanced epithelial ovarian cancer who developed bilateral total loss of hearing and acute renal failure related with paclitaxel- and carboplatin-based chemotherapy. Acute renal failure accompanied by complete loss of hearing in patients treated with carboplatin and paclitaxel combination has not been previously reported. This uncommon adverse effect of carboplatin and paclitaxel combination was discussed, and all the literature in English related with the toxicity of paclitaxel and carboplatin were reviewed.

  • acute renal failure
  • carboplatin
  • loss of hearing
  • paclitaxel

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