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Recurrent ovarian cancer metastatic to the sternum, costae, and thoracic wall after prolonged treatment with platinum-based chemotherapy: a case report and review of the literature
  1. G. Pavlakis*,
  2. G. Mountzios*,
  3. E. Terpos,
  4. A. Leivaditou,
  5. G. Papadopoulos* and
  6. P. Papasavas*
  1. * Departments of Medical Oncology, 251 General Airforce Hospital, Athens, Greece
  2. Departments of Haematology, 251 General Airforce Hospital, Athens, Greece
  3. Departments of Pathology, 251 General Airforce Hospital, Athens, Greece
  1. Address correspondence and reprint requests to: Giannis Mountzios, Department of Medical Oncology, 251 General Airforce Hospital, 3 Kanellopoulou Street, P.C. 115 25, Athens, Greece. Email: gmountzios{at}


Sternal and costal metastases from ovarian cancer are extremely rare. We present here a case of a 47-year-old woman with thoracic wall metastasis from serous–papillary ovarian carcinoma that occurred 3 years after the initial diagnosis, although the patient had received various regimens of intense platinum-based chemotherapy. Special emphasis is given to the effects of alkylating agents, such as cisplatin and carboplatin, on the pattern of tumor spread. We also discuss the possible mechanisms through which the biologic and metastatic behavior of this tumor is expressed.

  • ovarian carcinoma
  • platinum-based chemotherapy
  • sternal and costal metastasis

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