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Image-guided biopsy in women with breast cancer presenting with peritoneal carcinomatosis
  1. M. J. Hewitt*,
  2. G. D. Hall,
  3. N. Wilkinson,
  4. T. J. Perren,
  5. G. Lane* and
  6. J. A. Spencer§
  1. * Department of Gynaecology, St. James's University Hospital, Leeds, England
  2. Cancer Research UK Clinical Centre, St. James's University Hospital, Leeds, England
  3. Departments of Pathology, St. James's University Hospital, Leeds, England
  4. § Departments of Clinical Radiology, St. James's University Hospital, Leeds, England
  1. Address correspondence and reprint requests to: Matthew J. Hewitt, MD, MRCOG, Department of Gynaecology Level 9, Gledhow Wing, St. James's University Hospital, Beckett Street, Leeds LS9 7TF, England. Email: (matt.hewitt{at}


When women with a history of breast cancer present with peritoneal carcinomatosis, the differential diagnosis lies between recurrent breast cancer or a new primary tumor. This scenario is of particular relevance to women with a BRCA gene mutation, who have a genetic predisposition to develop second primary tumors of the ovary, fallopian tube, and peritoneum. We describe the use of image-guided core biopsy as an alternative to laparoscopy or exploratory laparotomy in providing minimally invasive diagnosis in this increasingly common clinical dilemma.

  • breast cancer
  • computed tomography (CT) guidance
  • ovarian cancer
  • peritoneum neoplasms
  • ultrasound guidance

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