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Increased expression of galectin-1 during the progression of cervical neoplasia
  1. N. Kohrenhagen*,
  2. H. U. Volker,
  3. M. Kapp*,
  4. J. Dietl* and
  5. U. Kammerer*
  1. * Department of Obstetrics and Gynecology, Wuerzburg, Germany
  2. Department of Pathology, University of Wuerzburg, Wuerzburg, Germany
  1. Address correspondence and reprint requests to: Nico Kohrenhagen, MD, Department of Obstetrics and Gynaecology, University of Wuerzburg, Josef-Schneider-Str. 4, 97080 Wuerzburg, Germany. Email: kohrenhagen{at}


Galectin-1, a member of the β-galactoside-binding family, is widely expressed in epithelial and immune cells. It is involved in several normal and pathologic processes, such as cancer progression, metastasis, and immunobiology. Galectin-1 was found to be overexpressed in various cancer cells and the corresponding benign tissue. Therefore, it has been described as a marker for tumor progression in some malignancies. In the current study, the expression of galectin-1 was examined in 80 formalin-fixed, paraffin-embedded cervical tissues: 20 benign cervical specimen, 20 low-grade squamous intraepithelial lesions (LGSIL), 20 high-grade squamous intraepithelial lesions (HGSIL), and 20 invasive squamous cell carcinomas (ISCC). Immunohistochemical analyses showed that the intensity of the galectin-1 expression on stromal cells next to the transformed cells increased according to the pathologic grade: benign cervical tissue < LGSIL < HGSIL < ISCC (P < 0.001). The epithelial cells were always negative for galectin-1. These results suggest that galectin-1 expression on stromal cells increases with the histopathologic grade of cervical tissues, and it can be concluded that this increase is associated with the progression of cervical neoplasia.

  • cervical intraepithelial neoplasia
  • cervix neoplasm
  • galectin-1
  • immunohistochemistry
  • squamous cell

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