Article Text

Download PDFPDF
Impact of hemoglobin on survival of cervical carcinoma patients treated with concurrent chemoradiotherapy is dependent on lymph node metastasis findings by magnetic resonance imaging
  1. Y. S. Choi*,
  2. C. M. Yi*,
  3. J.-I. Sin,
  4. G. W. Ye,
  5. I. H. Shin§ and
  6. T. S. Lee*
  1. *Department of Obstetrics and Gynecology, Catholic University of Daegu, Daemyung-4-Dong, Namgu, Daegu, Korea
  2. Department of Microbiology, Catholic University of Daegu, Daemyung-4-Dong, Namgu, Daegu, Korea
  3. Department of Radiation Oncology, Catholic University of Daegu, Daemyung-4-Dong, Namgu, Daegu, Korea
  4. §Medical Statistics, Catholic University of Daegu, Daemyung-4-Dong, Namgu, Daegu, Korea
  1. Address correspondence and reprint requests to: Youn Seok Choi, MD, Department of Obstetrics and Gynecology, School of Medicine, Catholic University of Daegu, 3056-6, Daemyung-4-Dong, Namgu, Daegu 705-718, Korea. Email: drcys{at}cu.ac.kr

Abstract

The objective of this study was to confirm whether hemoglobin (Hb) levels during chemoradiotherapy are associated with survival in patients with locally advanced cervical carcinoma and to assess impact of the Hb level on survival according to lymph node (LN) metastasis. A retrospective review of 85 cervical carcinoma patients treated with concurrent chemoradiotherapy was conducted. The stage of disease ranged between FIGO stage IB and stage IVA. Disease-free and overall survivals were evaluated by univariate and multivariate analyses. After median follow-up of 35.7 months, 24 patients developed recurrence of disease and 14 patients died from their disease. Stage, LN metastasis, and squamous cell carcinoma antigen and Hb levels during chemoradiation were correlated significantly with survival (P < 0.05). Maintenance of Hb above 10.0 g/dL was associated with better survival (P < 0.05). However, no such benefits were observed in patients with LN metastasis by magnetic resonance imaging (MRI). Multivariate Cox regression hazard model showed that Hb levels during chemoradiation were an independent prognostic factor in patients without LN metastasis by MRI. Maintenance of Hb during chemoradiation is of benefit in cervical carcinoma patients without LN metastasis but not with LN metastasis by MRI.

  • cervical cancer
  • chemoradiation
  • hemoglobin
  • lymph node metastasis

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.