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Combretastatin A-1 phosphate potentiates the antitumor activity of carboplatin and paclitaxel in a severe combined immunodeficiency disease (SCID) mouse model of human ovarian carcinoma
  1. K. Staflin*,
  2. S. Järnum*,
  3. J. Hua*,
  4. G. Honeth*,
  5. P. Kannisto and
  6. M. Lindvall*
  1. *Department of Cell and Molecular Biology, Section for Tumor Biology, Lund University, Lund, Sweden
  2. Department of Obstetrics and Gynecology, University Hospital of Lund, Lund, Sweden
  1. Address correspondence and reprint request to: Paivi Kannisto, MD, PhD, Department of Obstetrics and Gynecology, University Hospital of Lund, 22185 Lund, Sweden. Email: paivi.kannisto{at}


In search for new therapeutic modalities to target epithelial ovarian carcinomas, we investigated the effect of the antiangiogenic drug combretastatin A-1 phosphate (CA1P) as a single treatment or in combination with established therapy, ie, carboplatin and paclitaxel. Five different human epithelial ovarian carcinoma cell lines were inoculated subcutaneously into FOX CHASE CB-77 severe combined immunodeficiency disease (SCID) mice. When tumors reached a volume of approximately 100 mm3, the treatment was initiated. All drugs were given intraperitoneally at weekly doses. CA1P was more effective as an antitumor agent than combretastatin A-4 phosphate as a single-drug treatment or in combination with carboplatin and paclitaxel. CA1P had a strong tumor outgrowth inhibiting effect on four out of five tumors included in this study. Comparing animals receiving CA1P with animals receiving a combination of carboplatin and paclitaxel, CA1P was more effective on two out of three tested tumors, whereas carboplatin and paclitaxel were more effective on one out of three of the tumors. We show that treatment of human ovarian carcinomas with CA1P in the SCID mouse model results in a strong antitumor effect both as a single-drug treatment and as an enhancement of the therapeutic effect in a combination treatment protocol with carboplatin and paclitaxel.

  • antiangiogenesis
  • carboplatin
  • human ovarian carcinoma
  • paclitaxel
  • SCID mice

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