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Primary vaginal adenocarcinoma of intestinal type arising from a tubulovillous adenoma
  1. W. A.A. Tjalma* and
  2. C. G.A. Colpaert
  1. * Department of Gynecology and Gynecologic Oncology, University Hospital Antwerpen (UZA), Edegem, Antwerpen, Belgium
  2. Department of Pathology, University Hospital Antwerpen (UZA), Edegem, Antwerpen, Belgium
  1. Address correspondence and reprint requests to: Wiebren A. A. Tjalma, MD, PhD, Department of Gynecology and Gynecological Oncology, University Hospital Antwerpen (UZA), Wilrijkstraat 10, 2650 Edegem, Antwerpen, Belgium. Email: wiebren.tjalma{at}


Enteric or intestinal-type neoplasms of the vagina are extremely rare. The present report describes a 55-year-old woman who presented with a 6-week history of postmenopausal bleeding. On clinical examination, a lesion on the posterior vaginal wall was noticed. Rectovaginal examination suggested a tumor in the rectovaginal septum. Biopsy revealed an adenocarcinoma of the intestinal type, with a small remnant of a villous adenoma. The histologic interpretation pointed in the direction of a metastatic gastrointestinal tumor; yet, clinical examination, rectoscopy, colonoscopy, magnetic resonance imaging (MRI) of the abdomen, and positron emission tomography (PET) scanning excluded this possibility. This led to the conclusion that the lesion was a primary intestinal-type adenocarcinoma of the vagina that had arisen from a vaginal villous adenoma. It is important to be aware of this tumor type and to distinguish them from metastatic colorectal adenocarcinoma in order to plan appropriate treatment.

  • adenocarcinoma
  • cloacogenic
  • colorectal
  • enteric
  • female genital tract
  • intestinal
  • tubulovillous adenoma
  • vagina

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