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Statistical analysis of pathologic risk factors for intramyometrial lymphvascular space involvement in myoinvasive endometrial carcinoma
  1. L. H. Honorè* and
  2. J. Hanson
  1. * Department of Laboratory Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada
  2. Department of Epidermiology, Cross Cancer Institute, Edmonton, Alberta, Canada
  1. Address correspondence and reprint requests to: Louis H. Honorè, MBChB, FRCPC, Department of Laboratory Medicine, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada. Email: lhonore{at}shaw.ca

Abstract

In a retrospective study using univariate analysis, we identified tumor type (nonendometrioid vs endometrioid), depth of myoinvasion (MI), mode of MI (infiltrative vs cohesive), and direct anatomic invasion of the cervical wall from the isthmus as significant positive risk factors for intramyometrial lymphvascular space involvement (LVSI). On multivariate analysis, tumor grade, depth of MI, and mode of MI retained their significance. We created a grid for the relative risks of LVSI with respect to these variables individually or in combination. We suggest that our indirect estimate of the risk of LVSI can help in assessing prognosis and determining the need for adjuvant therapy whenever LVSI is important in clinical decision making, but its pathologic diagnosis is uncertain.

  • endometrial carcinoma
  • lymphvascular space involvement
  • relative risk
  • surgicopathologic variables
  • univariate and multivariate analysis

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