Article Text

Download PDFPDF
COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival
  1. R. Athavale*,
  2. K. Clooney,
  3. J. O'HAGAN,
  4. H. Shawki§,
  5. A. H. Clark and
  6. J. A. Green
  1. * Department of Gynaecological Oncology, Queen Elizabeth Hospital, Gateshead, United Kingdom
  2. Department of Pathology, Arrowe Park Hospital, Wirral, United Kingdom
  3. Department of Medical Oncology, Clatterbridge Centre for Oncology, Wirral, Merseyside, United Kingdom
  4. § Department of Pathology, Royal Liverpool Hospital, Liverpool, United Kingdom
  5. Department of Pathology, Arrowe Park Hospital, Wirral, United Kingdom
  6. Department of Medicine, University of Liverpool, Liverpool, United Kingdom
  1. Address correspondence and reprint requests to: Ram Athavale, MD, MRCOG, Queen Elizabeth Hospital, Sheriff Hill, Gateshead NE9 6SX, UK. Email: rathavale{at}


COX-1 and COX-2 are members of the cyclooxygenase (COX) family, which influence tumor invasion and apoptosis. The objective of the study was to assess the relationship between COX-1 and COX-2 expression in early-stage disease and subsequent disease relapse and long-term survival. Women with FIGO stage I and II cervical carcinoma, younger than 50 years, treated between 1981 and 1990 were included. COX-1 and COX-2 expressions in the tumors were assessed by immunohistochemistry. COX-1 and COX-2 were expressed in 61% (17/28) and 57% (16/28) of tumors, respectively. COX-1 nonexpressers showed an improved overall survival compared to expressers (log-rank test, P = 0.09). There was no significant difference in the overall survival in COX-2 nonexpressers compared to expressers (P = 0.6). Out of eight women with disease relapse, COX-1 or COX-2 expression was noted in six of eight tumors, and both were expressed in five of eight tumors. Our preliminary data suggest an adverse prognosis with COX-1 expression in early-stage cervical carcinoma and a trend toward COX-1 expression in disease relapse. The association between COX-2 expression and a worse prognosis was not proven in this study.

  • cervical carcinoma
  • COX-1
  • COX-2

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.