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The role of pretreatment squamous cell carcinoma antigen level in locally advanced squamous cell carcinoma of the uterine cervix treated by radiotherapy
  1. I. Ogino*,
  2. H. Nakayama,
  3. N. Okamoto,
  4. T. Kitamura§ and
  5. T. Inoue*
  1. * Department of Radiology, Yokohama City University, School of Medicine, Yokohama, Japan
  2. Department of Gynecology, Kanagawa Cancer Center, Yokohama, Japan
  3. Department of Epidemiology, Kanagawa Cancer Center, Yokohama, Japan
  4. § Radiation Oncology, Kanagawa Cancer Center, Yokohama, Japan
  1. Address correspondence and reprint requests to: Ichiro Ogino, MD, Department of Radiology, Yokohama City University, School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. Email:


The purpose of this study was to determine the pretreatment serum squamous cell carcinoma antigen (SCC-ag) level as a generally applicable measurement in predicting and estimating the treatment outcome of patients with locally advanced SCC of the cervix. Three hundred fifty-two patients with stage IIB–IVA SCC of the cervix were managed with both external irradiation and high–dose rate intracavitary brachytherapy. A significantly higher median SCC-ag was seen in association with increasing stage, tumor size, and lymph node involvement. The difference in disease-free survival (DFS) between stages IIB and III patients was not statistically significant with SCC-ag level <2 ng/mL. In multivariate analysis, median SCC-ag level (≥6.0 ng/mL) and lymph node metastases had significant independent effects on absolute survival and DFS. A direct linear relationship (y = −2.932x + 84.896) existed between the median SCC-ag of groups distributed by pretreatment prognostic factors and the 5-year DFS rate. The 5-year DFS rate as a function of SCC-ag level defined by cervix size, lymph node status, and hydronephrosis was obtained from a formula combining risk scores and the baseline survival function. From the obtained formulas, we can objectively estimate the treatment outcome in patients with locally advanced squamous cell cervical cancer.

  • cervical carcinoma
  • high–dose rate intracavitary brachytherapy
  • prognostic factors
  • radiation therapy
  • squamous cell carcinoma antigen

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