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Successful treatment of two patients with gestational trophoblastic neoplasm presenting with emergent neurologic symptoms
  1. F. Ghaemmaghami*,
  2. N. Behtash*,
  3. H. Ayatollahi* and
  4. P. Hanjani
  1. *Gynecology Oncology Department, Tehran University of Medical Sciences, Tehran, Iran
  2. Gynecology Oncology Department, Rosenfeld Cancer Center, Abington Memorial Hospital, Abington, Pennsylvania
  1. Address correspondence and reprint requests to: Fatemeh Ghaemmaghami, MD, Gynecology Oncology Department, Vali-e-Asr Hospital, Imam Khomeini Hospital Complex, Keshavarz Boulevard, Tehran 14194, Iran. Email: ftghaemmagh{at}


The objective of this study is to present the successful treatment of two young patients with gestational trophoblastic neoplasms (GTN) presenting with emergent neurologic symptoms without any gynecological problems. Case 1, a 22-year-old patient, was admitted to an infectious disease ward, with admitting diagnosis of encephalitis due to neurologic symptoms. Case 2, a 33-year-old patient, underwent craniotomy due to hemorrhagic brain tumor in the neurosurgery department. The diagnosis of GTN should be considered in any woman of reproductive age who has neurologic symptoms. It seems that multiagent chemotherapy in conjunction with whole-brain irradiation results in acceptable survival rate in brain metastatic GTN patients. Craniotomy is often necessary in fulminant cases.

  • brain metastatic GTN
  • choriocarcinoma
  • EMA-CO regimen
  • EMA-EP regimen
  • multiagent chemotherapy
  • WBRT

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