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Association between CD31 expression and histopathologic features in stage IB squamous cell carcinoma of the cervix
  1. A L Silva-Filho*,
  2. P. Traiman*,
  3. S. A. Triginelli,
  4. F. M. Reis,
  5. M. S. Pedrosa,
  6. D. Miranda,
  7. E. S. Abreu§,
  8. R. Macarenco§ and
  9. J R Cunha-Melo
  1. *Department of Obstetrics and Gynecology, Paulista State University, Botucatu, São Paulo, Brazil
  2. Department of Obstetrics and Gynecology, Belo Horizonte, Minas Gerais, Brazil
  3. Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  4. §Department of Pathology, Paulista State University, Botucatu, São Paulo, Brazil
  5. Department of Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  1. Address correspondence and reprint requests to: Dr Agnaldo Lopes Silva-Filho, MD, PhD, Department of Obstetrics and Gynecology, School of Medicine of the Federal University of Minas Gerais, Avenida Professor Alfredo Balena 190, Santa Efigênia, Belo Horizonte, Minas Gerais, Brazil 30130100. Email: agsilvaf{at}terra.com.br

Abstract

This study was undertaken to evaluate the association between the expression of CD31 in the tumor and the histopathologic findings in patients with carcinoma of the cervix. This study included prospectively 30 women, aged 46.6 ± 10.7 years, with stage IB squamous cell carcinoma of the cervix submitted to radical hysterectomy from November 2001 to September 2002. Samples from the tumor were taken and immunohistochemically evaluated by a monoclonal antibody for CD31. Clinicopathologic characteristics such as stage, tumor size, grade of differentiation, lymphatic vascular space invasion (LVSI), parametrial involvement, and status of pelvic lymph nodes were also recorded. The clinical stage (FIGO) was IB1 in 22 patients (73.3%) and IB2 in 8 patients (26.7%). The expression of CD31 was significantly associated with tumor size and the presence of LVSI, but not with grade of differentiation and vaginal or parametrial involvement (P= 0.03, P= 0.032, P= 0.352, P= 0.208, and P= 0.242, respectively). On univariate analysis, the presence of pelvic lymph node metastasis was influenced by LVSI (P= 0.003) and CD31 expression (P= 0.032). However, on multivariate analysis, the presence of LVSI (P= 0.007) was the only independent predictor of pelvic lymph node metastasis. The CD31 expression in tumor is significantly associated with LVSI and tumor size in patients with early-stage squamous cell carcinoma of the cervix.

  • angiogenesis
  • carcinoma
  • CD31
  • cervix

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