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Multinucleation of koilocytes is actually multilobation
  1. N. H. Cho*,
  2. S. Kang*,
  3. S. Hong*,
  4. G. B. Jeong,
  5. I. W. Choi,
  6. H. J. Choi and
  7. H. K. Choi
  1. *Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
  2. Department of Anatomy, Chungbuk Medical University, Chungju City, Korea
  3. Department of Computer Engineering, Inje University, Pusan, Korea
  1. Address correspondence and reprint requests to: Nam Hoon Cho, MD, Department of Pathology, Yonsei University College of Medicine, Seodaemoon-ku, Sinchon-dong 134, Seoul 120-752, Korea. Email: cho1988{at}


In order to clarify the complete cytomorphology of cytopathic changes as a consequence of human papillomavirus (HPV) infection, we performed three-dimensional (3D) reconstruction from confocal fluorescent images. After confirming 22 HPV types using a DNA chip, we performed 3D confocal image restoration in human uterine cervical swab samples and corresponding tumor tissues. On restoration of 3D confocal images, the multinucleated feature of koilocytes was revealed to be multilobation of a single nucleus, as opposed to true multinucleation.

  • confocal three-dimensional image
  • koilocytes
  • multilobation

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