Article Text

Download PDFPDF
Hyperbaric oxygen therapy for delayed radiation injuries in gynecological cancers
  1. D. Fink*,
  2. N. Chetty*,
  3. J. P. Lehm,
  4. D. E. Marsden* and
  5. N. F. Hacker*
  1. *Gynaecological Cancer Centre, Royal Hospital for Women, Sydney, Australia
  2. Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney, Australia
  1. Address correspondence and reprint requests to: Daniel Fink, MD, Division of Gynecology, University Hospital of Zurich, CH-8091 Zurich, Switzerland. Email: daniel.fink{at}


Delayed radiation-induced injuries are difficult to treat. The treatment of delayed radiation injuries with hyperbaric oxygen therapy (HBOT) is reported in small case series and case reports. This study reports the experience of a single institution with HBOT in delayed radiation injuries in patients with gynecological cancers. At least 20 sessions of 100% oxygen inhalation at 2.4 Atmospheric Absolutes (ATA) for 90 min in a hyperbaric chamber were carried out. Of the 14 patients included in the study, 10 patients have healed or showed improvement of more than 50%, resulting in a success rate of 71%. Mean follow-up was 31.6 months (range 6–70 months). The adverse events were acceptable. HBOT should be considered for patients with delayed radiation injuries, not responding to other treatments.

  • gynecological cancer
  • hyperbaric oxygen
  • radiation therapy

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.